Daughter of Emperor Maximilian I, Margaret was a Hapsburg princess and regent of the Netherlands. When she was three, she was betrothed to French dauphin and future King Charles VIII, who later renounced the agreement and married Anne of Brittany. In 1497, she married John of Spain—son of Ferdinand and Isabella—but he died later that year. In 1501, she married Philibert of Savoy; he died in 1504. In 1507, she was made regent of the Netherlands and guardian of what future Holy Roman Emperor? Discuss